O6-METHYLGUANINE-DNA METHYLTRANSFERASE IS DOWNREGULATED IN TRANSFORMED ASTROCYTE CELLS: IMPLICATIONS FOR ANTI-GLIOMA THERAPIES

O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

Abstract Background A novel alkylating agent, temozolomide, has proven efficacious Helicopter Kit in the treatment of malignant gliomas.However, expression of O6-methylguanine-DNA methyltransferase (MGMT) renders glioma cells resistant to the treatment, indicating that identification of mechanisms underlying the gene regulation of MGMT is highly re

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Signaletic, haptic and real-time material

This introductory article to the following “cluster of articles” proposes to apply the term “signal” as a theoretical and analytical category for a new approach to the bearings of electronic and new media in particular.As the term “sign” was formerly developed from linguistics, the term signal was developed

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Influence of Growth Stage and Leaf Age on Expression of the Components of Partial Resistance of Faba Bean to Botrytis fabae Sard.

In detached leaf tests on faba bean (Vicia faba L.), genotypes partially resistant and susceptible to Botrytis fabae were examined.Expression of four components of partial resistance to a virulent isolate of B.fabae differed Machines depending on the plant age and the leaf age of the genotypes.The incubation period of resistant genotypes at the pod

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